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Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM286333
Substrate
n/a
Meas. Tech.
HTRF-Based Assay
IC50
171±n/a nM
Citation
 Bennett, DJ; Cai, J; Carswell, E; Cooke, A; Hoyt, SB; London, C; MacLean, J; Ratcliffe, P; Taylor, JA; Xiong, Y; Samanta, SK; Kulkarni, BA Triazolopyridyl compounds as aldosterone synthase inhibitors US Patent  US9567333 Publication Date 2/14/2017 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:
Protein
Mol. Mass.:
57582.15
Organism:
Homo sapiens (Human)
Description:
P19099
Residue:
503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
  
Inhibitor
Name:
BDBM286333
Synonyms:
4-(8-chloro-[1,2,4] triazolo[1,5-a]pyridin-2- yl)isoquinoline | US9567333, 7
Type:
Small organic molecule
Emp. Form.:
C15H9ClN4
Mol. Mass.:
280.712
SMILES:
Clc1cccn2nc(nc12)-c1cncc2ccccc12
Structure:
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