Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM155348
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
pH
5.5±n/a
IC50
0.78±n/a nM
Comments
extracted
Citation
 Debenham, JSJiang, JMadsen-Duggan, CBShen, D Prolylcarboxypeptidase inhibitors US Patent  US9006268 Publication Date 4/14/2015 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM155348
Synonyms:
US9006268, 19
Type:
Small organic molecule
Emp. Form.:
C26H25FN4O
Mol. Mass.:
428.5013
SMILES:
Fc1ccc(cc1)-c1nc(c(o1)C1CCN(CCc2ccccc2)CC1)-c1ncccn1
Structure:
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