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Target
E3 ubiquitin-protein ligase XIAP
Ligand
BDBM156057
Substrate
n/a
Meas. Tech.
In vitro Competitive Displacement Binding Assays
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
270±n/a nM
Comments
extracted
Citation
 Woolford, AJ; Howard, S; Buck, IM; Chessari, G; Johnson, CN; Tamanini, E; Day, JE; Chiarparin, E; Heightman, TD; Frederickson, M; Griffiths-Jones, CM Bicyclic heterocycle compounds and their uses in therapy US Patent  US9018214 Publication Date 4/28/2015 
Target
Name:
E3 ubiquitin-protein ligase XIAP
Synonyms:
API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
56685.27
Organism:
Homo sapiens (Human)
Description:
P98170
Residue:
497
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
  
Inhibitor
Name:
BDBM156057
Synonyms:
US9018214, 108
Type:
Small organic molecule
Emp. Form.:
C22H31ClN4O3
Mol. Mass.:
434.96
SMILES:
C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ccc(Cl)cc23)[C@H](CN1)C(=O)N1CCOCC1 |r|
Structure:
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