Reaction Details Report a problem with these data
Target
Baculoviral IAP repeat-containing protein 2
Ligand
BDBM156019
Substrate
n/a
Meas. Tech.
In vitro Competitive Displacement Binding Assays
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
820±n/a nM
Comments
extracted
Citation
 Woolford, AJ; Howard, S; Buck, IM; Chessari, G; Johnson, CN; Tamanini, E; Day, JE; Chiarparin, E; Heightman, TD; Frederickson, M; Griffiths-Jones, CM Bicyclic heterocycle compounds and their uses in therapy US Patent  US9018214 Publication Date 4/28/2015 
Target
Name:
Baculoviral IAP repeat-containing protein 2
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | Baculoviral IAP repeat-containing protein 2 (cIAP1) | Cellular inhibitor of apoptosis 1 | Inhibitor of apoptosis protein 2 (cIAP1) | MIHB | RNF48
Type:
Protein
Mol. Mass.:
69900.47
Organism:
Homo sapiens (Human)
Description:
Q13490
Residue:
618
Sequence:
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS
  
Inhibitor
Name:
BDBM156019
Synonyms:
US9018214, 70
Type:
Small organic molecule
Emp. Form.:
C26H35N3O4S
Mol. Mass.:
485.639
SMILES:
COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ccc(cc12)S(=O)(=O)Cc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: