Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM287102
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
55.0±n/a nM
Comments
extracted
Citation
 Cuberes-Altisent, MR; Corbera-Arjona, J; Diaz-Fernandez, JL; Almansa-Rosales, C Pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma ligands US Patent  US9567338 Publication Date 2/14/2017 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM287102
Synonyms:
N-(1-(2- (Diisopropylamino)ethyl)- 1H-pyrazolo[3,4- d]pyrimidin-4-yl)-1- noradamantylcarboxamide hydrochloride | US9567338, 21
Type:
Small organic molecule
Emp. Form.:
C23H32N6O
Mol. Mass.:
408.5398
SMILES:
CC(C)N(CCn1ncc2c(NC(=O)C34C5CC33CC4CC3C5)ncnc12)C(C)C |TLB:20:21:14:16,16:15:19.20:17,18:19:22.15:17,12:14:21.22:16,12:14:21.20:18,THB:22:21:14:18,15:14:21.20:18,19:14:21.22:16,(2.42,-7.6,;2.02,-6.11,;.54,-5.71,;3.11,-5.02,;2.71,-3.53,;1.23,-3.13,;.83,-1.65,;1.73,-.4,;.83,.85,;-.64,.37,;-1.97,1.14,;-1.97,2.68,;-3.3,3.45,;-4.64,2.68,;-3.3,4.99,;-5.69,6.35,;-4.78,5.1,;-3.32,5.58,;-1.85,5.1,;-.95,6.35,;-1.85,7.6,;-3.32,7.12,;-4.78,7.6,;-3.3,.37,;-3.3,-1.17,;-1.97,-1.94,;-.64,-1.17,;4.6,-5.42,;5.69,-4.33,;5,-6.91,)|
Structure:
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