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Target
Tyrosine-protein kinase BTK [393-659]
Ligand
BDBM287428
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)
pH
6.5±n/a
Temperature
298.15±n/a K
IC50
<100±n/a nM
Comments
extracted
Citation
 Bonafoux, D; Davis, HM; Frank, KE; Friedman, MM; Herold, JM; Hoemann, MZ; Huntley, R; Osuma, A; Sheppard, G; Somal, GK; Van Camp, J; Van Epps, SA; Vasudevan, A; Wallace, GA; Wang, L; Wang, L; Wang, Z; Wilson, NS; Xu, X Primary carboxamides as BTK inhibitors US Patent  US9567339 Publication Date 2/14/2017 
Target
Name:
Tyrosine-protein kinase BTK [393-659]
Synonyms:
AGMX1 | ATK | BPK | BTK | BTK_HUMAN | Tyrosine-protein kinase BTK
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31165.48
Organism:
Homo sapiens (Human)
Description:
aa 393-659
Residue:
267
Sequence:
GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM287428
Synonyms:
US9567339, Example E.9.27
Type:
Small organic molecule
Emp. Form.:
C22H23N5O3
Mol. Mass.:
405.4497
SMILES:
NC(=O)c1ccc([C@@H]2CCN(C2)C(=O)C=C)c2cc([nH]c12)-c1cc2COCCn2n1 |r|
Structure:
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