Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM160571
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1220±n/a nM
Citation
 Li, J; Zhang, Q; Jia, Z; Wang, J Histone deacetylase inhibitor of benzamides and use thereof US Patent  US9040727 Publication Date 5/26/2015 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM160571
Synonyms:
US9040727, V-27
Type:
Small organic molecule
Emp. Form.:
C23H18FN3O2S
Mol. Mass.:
419.471
SMILES:
Nc1ccc(F)cc1NC(=O)c1ccc(CNC(=O)c2cc3ccccc3s2)cc1
Structure:
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