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Target
Coagulation factor XI
Ligand
BDBM161059
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
6732±n/a nM
Citation
 Orwat, MJ; Pinto, DJ; Smith, II, LM; Corte, JR; Srivastava, S Substituted 5,6,7,8-tetrahydro-1,6-naphthyridines as factor XIa inhibitors US Patent  US9108951 Publication Date 8/18/2015 
Target
Name:
Coagulation factor XI
Synonyms:
Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent
Type:
Enzyme
Mol. Mass.:
70130.58
Organism:
Homo sapiens (Human)
Description:
P03951
Residue:
625
Sequence:
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
  
Inhibitor
Name:
BDBM161059
Synonyms:
US9108951, 40 | US9394276, 40 | US9725435, 40
Type:
Small organic molecule
Emp. Form.:
C30H28ClN7O2
Mol. Mass.:
554.042
SMILES:
Clc1ccc(c(\C=C\C(=O)N2CCc3ccccc3[C@H]2C(=O)Nc2ccc(cc2)C2CCCN2)c1)-n1cnnn1 |r|
Structure:
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