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Target
C-C chemokine receptor-like 2
Ligand
BDBM163490
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
IC50
240±n/a nM
Citation
 Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z Cyclohexyl-azetidinyl antagonists of CCR2 US Patent  US9062048 Publication Date 6/23/2015 
Target
Name:
C-C chemokine receptor-like 2
Synonyms:
CCR11 | CCR6 | CCRL2 | CCRL2_HUMAN | CKRX | CRAM | HCR | Monocyte chemotactic protein-1 (MCP-1)
Type:
Protein
Mol. Mass.:
39518.98
Organism:
Homo sapiens (Human)
Description:
O00421
Residue:
344
Sequence:
MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
  
Inhibitor
Name:
BDBM163490
Synonyms:
US9062048, 116
Type:
Small organic molecule
Emp. Form.:
C21H27F3N6O
Mol. Mass.:
436.4739
SMILES:
NC[C@H]1CC[C@H](CC1)N1CC(C1)NC(=O)CNc1ncnc2ccc(cc12)C(F)(F)F |r,wU:2.1,5.8,(-8.95,-2.63,;-8.95,-1.09,;-7.61,-.32,;-7.61,1.22,;-6.28,1.99,;-4.94,1.22,;-4.94,-.32,;-6.28,-1.09,;-3.61,1.99,;-2.12,1.59,;-1.72,3.08,;-3.21,3.48,;-.39,3.85,;.94,3.08,;2.28,3.85,;.94,1.54,;2.28,.77,;2.28,-.77,;.94,-1.54,;.94,-3.08,;2.28,-3.85,;3.61,-3.08,;4.94,-3.85,;6.28,-3.08,;6.28,-1.54,;4.94,-.77,;3.61,-1.54,;7.61,-.77,;8.95,,;8.38,-2.1,;6.84,.56,)|
Structure:
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