Reaction Details Report a problem with these data
Target
Histone deacetylase 1/Nuclear receptor corepressor 2 [395-498]
Ligand
BDBM163629
Substrate
n/a
Meas. Tech.
HDAC Activity Assays
IC50
1.87e+3±n/a nM
Citation
Wang, Y; Stowe, RL; Pinello, CE; Tian, G; Madoux, F; Li, D; Zhao, LY; Li, JL; Wang, Y; Wang, Y; Ma, H; Hodder, P; Roush, WR; Liao, D Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol 22:273-84 (2015) [PubMed] Article
More Info.:
Target
Name:
Histone deacetylase 1/Nuclear receptor corepressor 2 [395-498]
Synonyms:
HDAC1/NCOR2
Type:
Protein
Mol. Mass.:
n/a
Description:
BPS Bioscience
Components:
This complex has 2 components.
Component 1
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
Component 2
Name:
Nuclear receptor corepressor 2 [395-498]
Synonyms:
CTG26 | Deacetylase activation domain (NCOR2) | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2
Type:
Protein
Mol. Mass.:
12719.17
Organism:
Homo sapiens (Human)
Description:
Deacetylase activation domain of human NCOR2 (395-498aa)
Residue:
104
Sequence:
IPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQ