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Target
AN1-type domain-containing protein
Ligand
BDBM50199883
Substrate
n/a
Meas. Tech.
Activity-based Protein Profiling (ABPP)
pH
7.4±0
Temperature
310.15±0 K
IC50
8.1e+3± 2.0e+3 nM
Citation
 Wolf, EV; Zeissler, A; Verhelst, SH Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing. ACS Chem Biol 10:2325-33 (2015) [PubMed]  Article 
Target
Name:
AN1-type domain-containing protein
Synonyms:
Rhomboid protease (AfROM)
Type:
Protein
Mol. Mass.:
37476.98
Organism:
Archaeoglobus fulgidus (AfROM)
Description:
O29251
Residue:
330
Sequence:
MLLHSFSRFKLLRGFLSLAAANYAMKHLPLFSTAVENFALFPRLPNSTQAEAFLTSRSLMLRVARCDVCGEEVTIPFKCKYCGGTFCAEHRLPENHDCDGLDEYWNVPVNVKRRLSPQPARRSRNIGLMKYGANNTVLIICTILFFISIVAPYEMVEIFALHPRLDVLLAMPWQLITSMFLHVEFWHFFVNMFVLLFFGTELERRLGDRKYLEIFFVSGLAGNVGYIAYSYAVGSFAPALGASAAIFGVMGCLAIIAPEIRIIIFPIPIPINIRTALLLFAAYDFWMMVASYMGLFYTNVANIAHLAGLAVGLYYGKRLGRRKVRYDFYF
  
Inhibitor
Name:
BDBM50199883
Synonyms:
3,4‐Dichloroisocoumarin (2) | 3,4-Dichloro-isochromen-1-one | 3,4-dichloro-1H-isochromen-1-one | 3,4-dichloroisocoumarin | CHEMBL24983 | cid_1609
Type:
Small organic molecule
Emp. Form.:
C9H4Cl2O2
Mol. Mass.:
215.033
SMILES:
Clc1oc(=O)c2ccccc2c1Cl
Structure:
Search PDB for entries with ligand similarity: