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Target
Rhomboid domain-containing protein
Ligand
BDBM165194
Substrate
n/a
Meas. Tech.
Activity-based Protein Profiling (ABPP)
pH
7.4±0
Temperature
310.15±0 K
IC50
1.7e+3± 2e+2 nM
Citation
Wolf, EV; Zeissler, A; Verhelst, SH Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing. ACS Chem Biol 10:2325-33 (2015) [PubMed] Article
More Info.:
Target
Name:
Rhomboid domain-containing protein
Synonyms:
Rhomboid protease (AaROM)
Type:
Protein
Mol. Mass.:
25597.66
Organism:
Aquifex aeolicus (Aquificales)
Description:
O67346
Residue:
227
Sequence:
MIPIKDVNPSRTFPIVNLSIIVACSLIWLYEWSLTDEVIYTFQGAVTKFELFLREWGLVPVELPQKPYTLLTHMFLHGSWGHIIGNMWFLWVFGDNVEDKLGKFRYIIFYILCGLGAALTQTFISLAFGGANVPMVGASGAISGVLGAYMKMFPHARVLALVPVFIFLTLMELPAVIFIGLWFFIQIINGIITLPFIGYGGVAWYAHIGGFITGYLLVDYFRKRSYS