Reaction Details Report a problem with these data
Target
Uncharacterized protein YOR062C
Ligand
BDBM166693
Substrate
n/a
Meas. Tech.
Tyrosinase Inhibition Assay
pH
6.8±n/a
IC50
9.103e+4± 2.19e+3 nM
Comments
extracted
Citation
 Xie, W; Zhang, J; Ma, X; Yang, W; Zhou, Y; Tang, X; Zou, Y; Li, H; He, J; Xie, S; Zhao, Y; Liu, F Synthesis and biological evaluation of kojic acid derivatives containing 1,2,4-triazole as potent tyrosinase inhibitors. Chem Biol Drug Des 86:1087-92 (2015) [PubMed]  Article 
Target
Name:
Uncharacterized protein YOR062C
Synonyms:
Tyrosinase | YO062_YEAST
Type:
Protein
Mol. Mass.:
31886.70
Organism:
Agaricus bisporus (Mushroom)
Description:
O00024
Residue:
268
Sequence:
MTSLDDSVLTKKNIALLDNATNYIRPAIDYFHFKFNYDSLDVSTTWRLLLKMRKHKLLRLPSCSSENEFDYSIYMARLYHCIWRRWSIKHFNLDEYKIDPLSINWNKEIDVTVLYGPDLVGIHEREQPTPTDFPMGNIKEQGKQLLDVRKEGSASSLLKKGSVFYSKGKWLSQRSISFDDTVRRRDIDKRGRFRESCVLINDVEQFQNYSIVWDESRHRYRRQALPDTYDYEHLYPNGDETPRNTPHDNIIIHQNLHSITEGSYIYIK
  
Inhibitor
Name:
BDBM166693
Synonyms:
5-methyl-3-[5-hydroxy-4-pyrone-2-yl-methylmercapto]-4-amino-1,2,4-triazole (6a)
Type:
Small organic molecule
Emp. Form.:
C9H10N4O3S
Mol. Mass.:
254.266
SMILES:
Cc1nnc(SCc2cc(=O)c(O)co2)n1N
Structure:
Search PDB for entries with ligand similarity: