Reaction Details Report a problem with these data
Target
Uncharacterized protein YOR062C
Ligand
BDBM166704
Substrate
n/a
Meas. Tech.
Tyrosinase Inhibition Assay
pH
6.8±n/a
IC50
5.98e+3± 4.2e+2 nM
Comments
extracted
Citation
 Xie, W; Zhang, J; Ma, X; Yang, W; Zhou, Y; Tang, X; Zou, Y; Li, H; He, J; Xie, S; Zhao, Y; Liu, F Synthesis and biological evaluation of kojic acid derivatives containing 1,2,4-triazole as potent tyrosinase inhibitors. Chem Biol Drug Des 86:1087-92 (2015) [PubMed]  Article 
Target
Name:
Uncharacterized protein YOR062C
Synonyms:
Tyrosinase | YO062_YEAST
Type:
Protein
Mol. Mass.:
31886.70
Organism:
Agaricus bisporus (Mushroom)
Description:
O00024
Residue:
268
Sequence:
MTSLDDSVLTKKNIALLDNATNYIRPAIDYFHFKFNYDSLDVSTTWRLLLKMRKHKLLRLPSCSSENEFDYSIYMARLYHCIWRRWSIKHFNLDEYKIDPLSINWNKEIDVTVLYGPDLVGIHEREQPTPTDFPMGNIKEQGKQLLDVRKEGSASSLLKKGSVFYSKGKWLSQRSISFDDTVRRRDIDKRGRFRESCVLINDVEQFQNYSIVWDESRHRYRRQALPDTYDYEHLYPNGDETPRNTPHDNIIIHQNLHSITEGSYIYIK
  
Inhibitor
Name:
BDBM166704
Synonyms:
5-(2-bromophenyl)-3-[5-hydroxy-4-pyrone-2-yl-methylmercapto]-4-amino-1,2,4-triazole (6l)
Type:
Small organic molecule
Emp. Form.:
C14H11BrN4O3S
Mol. Mass.:
395.231
SMILES:
Nn1c(SCc2cc(=O)c(O)co2)nnc1-c1ccccc1Br
Structure:
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