Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 3
Ligand
BDBM287915
Substrate
n/a
Meas. Tech.
Vasoreactivity in Rat Mesenteric Arteries In Vitro
EC50
13.8±n/a nM
Citation
 Selwood, D; Hobbs, A Agents for use in the treatment of cardiovascular and inflammatory diseases structurally based on 4(1 H)-quinolone US Patent  US10087144 Publication Date 10/2/2018 
Target
Name:
Atrial natriuretic peptide receptor 3
Synonyms:
ANP-C | ANPR-C | ANPRC | ANPRC_MOUSE | Atrial natriuretic peptide C-type receptor | Atrial natriuretic peptide clearance receptor | Atrial natriuretic peptide receptor 3 | Atrial natriuretic peptide receptor C | EF-2 | NPR-C | Npr3
Type:
PROTEIN
Mol. Mass.:
59812.13
Organism:
Mus musculus
Description:
ChEMBL_35004
Residue:
536
Sequence:
MRSLLLFTFSACVLLARVLLAGGASSGAGDTRPGSRRRAREALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWRRGDKHDSEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFQMRSNVKYPWGPLKLRLDETRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNQQEESNIGKHRELREDSIRSHFSVA
  
Inhibitor
Name:
BDBM287915
Synonyms:
CNP-22 | CNP-53 | Natriuretic peptide, C-type | US10087144, Compound CNP
Type:
Small organic molecule
Emp. Form.:
C93H157N27O28S3
Mol. Mass.:
2197.601
SMILES:
CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CN
Structure:
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