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Target
Histone deacetylase 1
Ligand
BDBM172895
Substrate
n/a
Meas. Tech.
Flag Assay
IC50
16±n/a nM
Citation
 Harrington, P; Heidebrecht, Jr., RW; Kattar, S; Miller, TA; Otte, KM; Siliphaivanh, P; Stanton, MG; Tempest, P; Wilson, KJ; Witter, DJ 4-carboxybenzylamino derivatives as histone deacetylase inhibitors US Patent  US9096559 Publication Date 8/4/2015 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM172895
Synonyms:
US9096559, 1
Type:
Small organic molecule
Emp. Form.:
C27H23N4O3
Mol. Mass.:
451.4971
SMILES:
Nc1ccc(cc1NC(=O)c1ccc(CN(Cc2cccnc2)C([O-])=O)cc1)-c1ccccc1
Structure:
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