Reaction Details Report a problem with these data
Target
Focal adhesion kinase 1
Ligand
BDBM176596
Substrate
n/a
Meas. Tech.
Biacore SPR Assay
pH
7.4±n/a
Kd
0.79±n/a nM
Comments
extracted
Citation
 Holmes, IP; Bergman, Y; Lunniss, GE; Nikac, M; Chol, N; Hemley, CF; Walker, SR; Foitzik, RC; Ganame, D; Lessene, R Selective FAK inhibitors US Patent  US9120761 Publication Date 9/1/2015 
Target
Name:
Focal adhesion kinase 1
Synonyms:
FAK1_MOUSE | Fadk | Fak | Fak1 | Focal adhesion kinase (FAK) | Kiaa4203 | Ptk2
Type:
Enzyme
Mol. Mass.:
123537.99
Organism:
Mus musculus (Mouse)
Description:
P34152
Residue:
1052
Sequence:
MAAAYLDPNLNHTPSSSTKTHLGTGMERSPGAMERVLKVFHYFESSSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMQEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGIPAMAGSIYQGQASLLDQTELWNHRPQEMSMWQPSVEDSAALDLRGMGQVLPPHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSFQGPTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLSNLSSISSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPALPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
  
Inhibitor
Name:
BDBM176596
Synonyms:
US9120761, 10
Type:
Small organic molecule
Emp. Form.:
C27H27F6N5O2
Mol. Mass.:
567.526
SMILES:
NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(cc2OC(F)(F)F)C2CCNCC2)ncc1C(F)(F)F
Structure:
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