Reaction Details Report a problem with these data
Target
Amine oxidase
Ligand
BDBM24777
Substrate
n/a
Meas. Tech.
MAO Inhibition Assay
IC50
4.36e+3± 1.8e+2 nM
Citation
 Mostert, S; Petzer, A; Petzer, JP Evaluation of Natural and Synthetic 1,4-naphthoquinones as Inhibitors of Monoamine Oxidase. Chem Biol Drug Des 87:737-46 (2016) [PubMed]  Article 
Target
Name:
Amine oxidase
Synonyms:
Monoamine oxidase B (MAO-B)
Type:
Protein
Mol. Mass.:
58780.23
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDHVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIQSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM24777
Synonyms:
5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hydroxy-1,4-naphthoquinone, 4 | CHEMBL43612 | Juglone | Juglone (6a)
Type:
Small organic molecule
Emp. Form.:
C10H6O3
Mol. Mass.:
174.1528
SMILES:
Oc1cccc2C(=O)C=CC(=O)c12 |c:8|
Structure:
Search PDB for entries with ligand similarity: