Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM178477
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
500±n/a nM
Citation
 Demchenko, A; Nichols, MR; Kaeothip, S Saccharide conjugates US Patent  US9120838 Publication Date 9/1/2015 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM178477
Synonyms:
US9120838, 24
Type:
Small organic molecule
Emp. Form.:
C58H91NO13
Mol. Mass.:
1010.342
SMILES:
CCCCCCCCCCCCCCO[C@H]1[C@@H](OC)O[C@H](COC(=O)CCC(=O)OC[C@H](NC(=O)OCC2c3ccccc3-c3ccccc23)C(O)=O)[C@@H](OC)[C@@H]1OCCCCCCCCCCCCCC
Structure:
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