Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM179593
Substrate
n/a
Meas. Tech.
Surface plasmon resonance (SPR)
IC50
268.82±n/a nM
Citation
 Visser, MS; Yusuff, N Compounds for inhibiting the interaction of BCL2 with binding partners US Patent  US9126980 Publication Date 9/8/2015 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM179593
Synonyms:
US9126980, 38
Type:
Small organic molecule
Emp. Form.:
C36H40BrF2N5O4S
Mol. Mass.:
756.7
SMILES:
CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cc(F)c(Br)cc2F)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Structure:
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