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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM180490
Substrate
n/a
Meas. Tech.
AlphaScreen cAMP Assay
pH
7.4±n/a
Temperature
310.15±n/a K
EC50
189±n/a nM
Comments
extracted
Citation
 Grauert, M; Bakker, R; Breitfelder, S; Buettner, F; Eickelmann, P; Fox, T; Grundl, M; Lehmann-Lintz, T; Rist, W Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists US Patent  US8772323 Publication Date 7/8/2014 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM180490
Synonyms:
US8772323, 52
Type:
Small organic molecule
Emp. Form.:
C22H23N3O3
Mol. Mass.:
377.4363
SMILES:
CCCOc1ccc(cc1)-c1nc2ccc(cc2o1)C1=NNC(=O)CC1CC |t:22|
Structure:
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