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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM181730
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
71±n/a nM
Comments
extracted
Citation
 Walsh, SP; Pasternak, A; DeJesus, RK; Tang, H; Pio, B; Shahripour, A; Belyk, KM; Chobanian, HR; Guo, Y; Frie, JL; Shi, Z; Chen, H; Blizzard, TA; Cato, B Inhibitors of the Renal Outer Medullary Potassium channel US Patent  US9139585 Publication Date 9/22/2015 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM181730
Synonyms:
US9139585, 25 | US9139585, 26
Type:
Small organic molecule
Emp. Form.:
C26H30N4O6
Mol. Mass.:
494.5396
SMILES:
COc1cc(ncc1[N+]#[C-])C(O)CN1C2COCC1CN(C[C@H](O)c1ccc3C(=O)OCc3c1C)C2 |r,THB:21:20:13:15.17.16|
Structure:
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