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Target
RAC-alpha serine/threonine-protein kinase
Ligand
BDBM182362
Substrate
n/a
Meas. Tech.
AKT Enzyme Assay
pH
7.5±n/a
IC50
130±n/a nM
Comments
extracted
Citation
 Lan, R; Huck, BR; Xiao, Y; Chen, X; Deselm, LC; Qiu, H; Neagu, C; Bankston, D; Jones, CC Imidazole amines as modulators of kinase activity US Patent  US9145392 Publication Date 9/29/2015 
Target
Name:
RAC-alpha serine/threonine-protein kinase
Synonyms:
AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)
Type:
Enzyme
Mol. Mass.:
55681.25
Organism:
Homo sapiens (Human)
Description:
P31749
Residue:
480
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM182362
Synonyms:
US9145392, 63
Type:
Small organic molecule
Emp. Form.:
C32H34F5N7
Mol. Mass.:
611.6513
SMILES:
Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCCCC2)-c2ccc(F)c(c2)C(F)(F)F)c1-c1ccccc1F |(3.16,-8.47,;1.83,-7.7,;.49,-8.47,;-.84,-7.7,;-.84,-6.16,;.49,-5.39,;.49,-3.85,;1.83,-3.08,;1.83,-1.54,;.49,-.77,;-.84,-1.54,;-.84,-3.08,;.49,.77,;1.74,1.67,;1.26,3.14,;-.28,3.14,;-.75,1.67,;-2.09,.9,;-3.42,1.67,;-4.75,.9,;-6.09,1.67,;-7.42,.9,;-7.42,-.64,;-6.09,-1.41,;-4.75,-.64,;2.03,4.47,;1.26,5.8,;2.03,7.14,;3.57,7.14,;4.34,8.47,;4.34,5.8,;3.57,4.47,;5.88,5.8,;7.42,5.8,;6.65,7.14,;6.65,4.47,;1.83,-6.16,;3.16,-5.39,;3.16,-3.85,;4.49,-3.08,;5.83,-3.85,;5.83,-5.39,;4.49,-6.16,;4.49,-7.7,)|
Structure:
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