Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM184638
Substrate
n/a
Meas. Tech.
Radioligand Binding
pH
7.4±n/a
Temperature
277.15±n/a K
IC50
2050±n/a nM
Comments
extracted
Citation
 Donde, Y; Nguyen, JH; Kedzie, KM; Gil, DW; Donello, JE; Im, W Treatment of inflammatory bowel disease US Patent  US9156810 Publication Date 10/13/2015 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM184638
Synonyms:
US9156810, (74, 75)
Type:
Small organic molecule
Emp. Form.:
C26H30O5S
Mol. Mass.:
454.578
SMILES:
CC1(C)[C@@H](O)[C@H](\C=C\C(O)Cc2cc3ccccc3s2)[C@@H](CC#CCCCC(O)=O)C1=O
Structure:
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