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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM186145
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Temperature
298.15±n/a K
IC50
3.07±n/a nM
Comments
extracted
Citation
 Claremon, DA; Tice, CM; Zhuang, L; Leftheris, K; Ye, Y; Singh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent  US9163012 Publication Date 10/20/2015 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM186145
Synonyms:
US9163012, 62
Type:
Small organic molecule
Emp. Form.:
C24H30N4O4
Mol. Mass.:
438.5194
SMILES:
Cn1c2ccccc2n([C@@H]2CCN(C2)C(=O)O[C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)c1=O |r,wU:17.18,9.9,wD:24.31,TLB:17:18:25:23.22.21,16:17:23:25.20.21,THB:17:22:25:18.19.26,19:18:23:25.20.21,19:20:23:18.17.26,(8.47,2.95,;7.14,2.18,;7.14,.64,;8.28,-.4,;7.96,-1.9,;6.5,-2.38,;5.35,-1.35,;5.67,.16,;4.77,1.41,;3.23,1.41,;2.32,2.65,;.86,2.18,;.86,.64,;2.32,.16,;-.48,-.13,;-.48,-1.67,;-1.81,.64,;-3.14,-.13,;-3.14,-1.67,;-4.04,-3.6,;-5.24,-2.93,;-5.23,-.53,;-4.47,.63,;-5.8,-.13,;-5.8,-1.67,;-6.64,-3.58,;-4.47,-2.45,;-7.14,-2.44,;-8.47,-1.67,;-7.14,-3.98,;5.67,2.65,;4.9,3.98,)|
Structure:
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