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Target
Cyclin-dependent kinase 16
Ligand
BDBM186184
Substrate
n/a
Meas. Tech.
LanthaScreen TR-FRET Assay
Temperature
295.15±n/a K
IC50
1.50e+3±n/a nM
Comments
extracted
Citation
 Alisi, MA; Cazzolla, N; Garofalo, B; Furlotti, G; Magaro′, G; Ombrato, R; Mancini, F Use of 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors US Patent  US9163013 Publication Date 10/20/2015 
Target
Name:
Cyclin-dependent kinase 16
Synonyms:
CDK16 | CDK16_HUMAN | PCTAIRE1 | PCTK1 | Serine/threonine-protein kinase PCTAIRE-1
Type:
Protein
Mol. Mass.:
55721.58
Organism:
Homo sapiens (Human)
Description:
Q00536
Residue:
496
Sequence:
MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF
  
Inhibitor
Name:
BDBM186184
Synonyms:
US9163013, 1
Type:
Small organic molecule
Emp. Form.:
C23H28N4O3
Mol. Mass.:
408.4934
SMILES:
COc1ccc2[nH]nc(C(=O)NCC3CCN(CCc4ccc(O)cc4)CC3)c2c1
Structure:
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