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Target
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Ligand
BDBM188295
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7±n/a
IC50
<40±n/a nM
Comments
extracted
Citation
 Wong, C; Wu, Y Compounds and methods for treating tuberculosis infection US Patent  US9073941 Publication Date 7/7/2015 
Target
Name:
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Synonyms:
ODP2_MYCTU | Pyruvate dehydrogenase (PDH) | dlaT | sucB
Type:
Enzyme
Mol. Mass.:
57069.35
Organism:
Mycobacterium tuberculosis
Description:
P9WIS7
Residue:
553
Sequence:
MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKPAPEPPPVQPTSGAPAGGDAKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVAGVLVSISADEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPAPTPKAEPAPSPPAAQPAGAAEGAPYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDVLAAAEQKKRAKAPAPAAQAAAAPAPKAPPAPAPALAHLRGTTQKASRIRQITANKTRESLQATAQLTQTHEVDMTKIVGLRARAKAAFAEREGVNLTFLPFFAKAVIDALKIHPNINASYNEDTKEITYYDAEHLGFAVDTEQGLLSPVIHDAGDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYLPLTYDHRLIDGADAGRFLTTIKHRLEEGAFEADLGL
  
Inhibitor
Name:
BDBM188295
Synonyms:
US9073941, 701
Type:
Small organic molecule
Emp. Form.:
C13H13N5O2
Mol. Mass.:
271.2746
SMILES:
CN1N=C(Nc2c1nc(O)n(C)c2=O)c1ccccc1 |c:2|
Structure:
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