Reaction Details Report a problem with these data
Target
Serum paraoxonase/arylesterase 1
Ligand
BDBM189358
Substrate
n/a
Meas. Tech.
Paraoxonase Activity Assay
pH
10.5±n/a
Ki
8.973e+6± 9.55e+5 nM
IC50
2.3300e+7±n/a nM
Comments
extracted
Citation
 Alim, Z; Beydemir, S Some Anticancer Agents Act on Human Serum Paraoxonase-1 to Reduce Its Activity. Chem Biol Drug Des 88:188-96 (2016) [PubMed]  Article 
Target
Name:
Serum paraoxonase/arylesterase 1
Synonyms:
A-esterase 1 | Aromatic esterase 1 | K-45 | PON | PON 1 | PON1 | PON1_HUMAN | Paraoxonase (PON1) | Paraoxonase (hPON1) | Paraoxonase 1 (PON1) | Serum aryldialkylphosphatase 1 | Serum paraoxonase 1 (PON1)
Type:
Enzyme
Mol. Mass.:
39719.73
Organism:
Homo sapiens (Human)
Description:
P27169
Residue:
355
Sequence:
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
  
Inhibitor
Name:
BDBM189358
Synonyms:
Asta Z 4942 | Ifosfamide | Iphosphamide | N,3-bis(2-chloroethyl)-2-oxo-1,3,2-oxazaphosphinan-2-amine
Type:
Small organic molecule
Emp. Form.:
C7H15Cl2N2O2P
Mol. Mass.:
261.086
SMILES:
ClCCNP1(=O)OCCCN1CCCl
Structure:
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