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Target
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)
Ligand
BDBM193248
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
1±n/a nM
Citation
 Player, MR; Meegalla, SK; Illig, CR; Chen, J; Wilson, KJ; Lee, Y; Parks, DJ; Cheung, WS; Huang, H; Patch, RJ PDE 10a inhibitors for the treatment of type II diabetes US Patent  US9193736 Publication Date 11/24/2015 
Target
Name:
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)
Synonyms:
PDE10A | PDE10_HUMAN | Phosphodiesterase 10A | Phosphodiesterase 10A (PDE10A2) | Phosphodiesterase 10A2 | Phosphodiesterase 10A2 (PDE10A) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)
Type:
Enzyme
Mol. Mass.:
89387.03
Organism:
Homo sapiens (Human)
Description:
Q9Y233-2
Residue:
789
Sequence:
MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
  
Inhibitor
Name:
BDBM193248
Synonyms:
US9193736, 172
Type:
Small organic molecule
Emp. Form.:
C34H35N5O3
Mol. Mass.:
561.6734
SMILES:
CC(C)(CC(O)=O)c1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)[C@H]1C[C@@H](C1)c1ccc2ccccc2n1 |wU:28.31,wD:30.36,(.91,-5.51,;-.12,-4.37,;-1.16,-3.22,;-1.27,-5.4,;-.95,-6.9,;-2.09,-7.94,;.52,-7.38,;1.02,-3.34,;.7,-1.83,;1.84,-.8,;3.31,-1.28,;3.63,-2.78,;2.48,-3.81,;4.45,-.25,;4.29,1.29,;5.7,1.91,;6.73,.77,;8.27,.77,;9.04,-.57,;8.27,-1.9,;6.73,-1.9,;5.96,-.57,;9.04,2.1,;8.27,3.43,;9.04,4.77,;10.58,4.77,;11.35,3.43,;10.58,2.1,;2.96,2.06,;1.47,1.66,;1.07,3.14,;2.56,3.54,;-.26,3.91,;-.26,5.45,;-1.6,6.22,;-2.93,5.45,;-4.26,6.22,;-5.6,5.45,;-5.6,3.91,;-4.26,3.14,;-2.93,3.91,;-1.6,3.14,)|
Structure:
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