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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM195917
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
320±n/a nM
Citation
 Pio, B; Pasternak, A; Shahripour, A; Tang, H; Walsh, S Inhibitors of the renal outer medullary potassium channel US Patent  US9206199 Publication Date 12/8/2015 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM195917
Synonyms:
US9206199, 18
Type:
Small organic molecule
Emp. Form.:
C22H23N9O2
Mol. Mass.:
445.4771
SMILES:
Cc1c(cccc1[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1cnc(nc1)-n1cnnn1)[N+]#[C-] |r|
Structure:
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