Reaction Details Report a problem with these data
Target
P2X purinoceptor 3
Ligand
BDBM196390
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
IC50
11±n/a nM
Comments
extracted
Citation
 Kai, H; Endoh, T; Jikihara, S; Horiguchi, T Heterocyclic derivative and pharmaceutical composition comprising the same US Patent  US9212130 Publication Date 12/15/2015 
Target
Name:
P2X purinoceptor 3
Synonyms:
ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa
Type:
Protein
Mol. Mass.:
44292.02
Organism:
Homo sapiens (Human)
Description:
P56373
Residue:
397
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
  
Inhibitor
Name:
BDBM196390
Synonyms:
US9212130, I-312
Type:
Small organic molecule
Emp. Form.:
C26H27N5O3S2
Mol. Mass.:
521.654
SMILES:
CSc1ccc(Cn2c(Nc3ccc4nc(C)sc4c3)ncc(NC(=O)C3CCOCC3)c2=O)cc1
Structure:
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