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Target
Kallikrein-1
Ligand
BDBM200075
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
IC50
8400±n/a nM
Citation
 Evans, DM; Davie, RL; Edwards, HJ; Rooker, DP Benzylamine derivatives as inhibitors of plasma kallikrein US Patent  US9234000 Publication Date 1/12/2016 
Target
Name:
Kallikrein-1
Synonyms:
KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:
Enzyme
Mol. Mass.:
28874.69
Organism:
Homo sapiens (Human)
Description:
P06870
Residue:
262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
  
Inhibitor
Name:
BDBM200075
Synonyms:
US9234000, 66
Type:
Small organic molecule
Emp. Form.:
C32H40N4O4
Mol. Mass.:
544.6844
SMILES:
CCOc1ccc(C[C@H](N(C)C(=O)CC)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCc2ccc(CN)cc2)cc1
Structure:
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