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Target
Kallikrein-7 [37-253,Y180R]
Ligand
BDBM203868
Substrate
n/a
Meas. Tech.
Human KLK7 Fluorescence-Lifetime Assay
pH
5.6±n/a
Temperature
298.15±n/a K
IC50
>1.00e+5±n/a nM
Comments
extracted
Citation
 Maibaum, J; Liao, SM; Vulpetti, A; Ostermann, N; Randl, S; Rüdisser, S; Lorthiois, E; Erbel, P; Kinzel, B; Kolb, FA; Barbieri, S; Wagner, J; Durand, C; Fettis, K; Dussauge, S; Hughes, N; Delgado, O; Hommel, U; Gould, T; Mac Sweeney, A; Gerhartz, B; Cumin, F; Flohr, S; Schubart, A; Jaffee, B; Harrison, R; Risitano, AM; Eder, J; Anderson, K Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat Chem Biol 12:1105-1110 (2016) [PubMed]  Article 
Target
Name:
Kallikrein-7 [37-253,Y180R]
Synonyms:
KLK7 | KLK7_HUMAN | Kalligrein-7 Y180R (KLK7) | PRSS6 | SCCE
Type:
Protein
Mol. Mass.:
23785.70
Organism:
Homo sapiens (Human)
Description:
P49862 (37-253 aa with Y180R mutation)
Residue:
217
Sequence:
ARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVRKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM203868
Synonyms:
(S)-N2-benzhydryl-N1-(1-methyl-1H-indol-3-yl)pyrrolidine-1,2-dicarboxamide (5)
Type:
Small organic molecule
Emp. Form.:
C28H28N4O2
Mol. Mass.:
452.5475
SMILES:
Cn1cc(NC(=O)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: