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Target
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)
Ligand
BDBM204837
Substrate
n/a
Meas. Tech.
LanthaScreen Kinase Assay
pH
7.5±n/a
IC50
80±n/a nM
Comments
extracted
Citation
 Takeuchi, J; Ikura, M; Higashino, M; Iwahashi, M; Hashimura, K Trk-inhibiting compound US Patent  US9242977 Publication Date 1/26/2016 
Target
Name:
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)
Synonyms:
High affinity nerve growth factor receptor (TrkAI) | MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA | Tyrosine kinase receptor A (Trk-A)
Type:
Enzyme
Mol. Mass.:
86881.47
Organism:
Homo sapiens (Human)
Description:
P04629-2
Residue:
790
Sequence:
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
  
Inhibitor
Name:
BDBM204837
Synonyms:
US9242977, 65-1
Type:
Small organic molecule
Emp. Form.:
C33H34N8O3S
Mol. Mass.:
622.74
SMILES:
Cc1ccc(cc1C)-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(C)C
Structure:
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