Reaction Details Report a problem with these data
Target
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)
Ligand
BDBM204849
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2±n/a nM
Citation
 Takeuchi, J; Ikura, M; Higashino, M; Iwahashi, M; Hashimura, K Trk-inhibiting compound US Patent  US9242977 Publication Date 1/26/2016 
Target
Name:
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)
Synonyms:
High affinity nerve growth factor receptor (TrkAI) | MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA | Tyrosine kinase receptor A (Trk-A)
Type:
Enzyme
Mol. Mass.:
86881.47
Organism:
Homo sapiens (Human)
Description:
P04629-2
Residue:
790
Sequence:
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
  
Inhibitor
Name:
BDBM204849
Synonyms:
US9242977, 85-184
Type:
Small organic molecule
Emp. Form.:
C28H22F6N8O2S
Mol. Mass.:
648.582
SMILES:
CCCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3ccc(n3)C(F)(F)F)C(F)(F)F)cn2)cc1
Structure:
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