Reaction Details Report a problem with these data
Target
Uracil-DNA glycosylase
Ligand
BDBM208054
Substrate
n/a
Meas. Tech.
Viral Plaque Reduction Assay
Temperature
310.15±n/a K
IC50
18000±0 nM
Comments
extracted
Citation
 Ricciardi, RP; Nuth, M Potent poxvirus inhibitor US Patent  US9233921 Publication Date 1/12/2016 
Target
Name:
Uracil-DNA glycosylase
Synonyms:
OPG116 | UNG | UNG_VACCC | vaccinia virus D4/A20
Type:
n/a
Mol. Mass.:
25083.53
Organism:
Vaccinia virus (strain Copenhagen) (VACV)
Description:
P20536
Residue:
218
Sequence:
MNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITKHVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEIINVLLELDNKVPINWAQGFIY
  
Inhibitor
Name:
BDBM208054
Synonyms:
4-Methyl-3-((2,4,5-trichlorophenyl)thio)-1H-indole-2-carboxylic acid | US9233921, 30b
Type:
Small organic molecule
Emp. Form.:
C16H10Cl3NO2S
Mol. Mass.:
386.68
SMILES:
Cc1cccc2[nH]c(C(O)=O)c(Sc3cc(Cl)c(Cl)cc3Cl)c12
Structure:
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