Reaction Details Report a problem with these data
Target
Uracil-DNA glycosylase
Ligand
BDBM208057
Substrate
n/a
Meas. Tech.
Viral Plaque Reduction Assay
Temperature
310.15±n/a K
IC50
208±42 nM
Comments
extracted
Citation
 Ricciardi, RP; Nuth, M Potent poxvirus inhibitor US Patent  US9233921 Publication Date 1/12/2016 
Target
Name:
Uracil-DNA glycosylase
Synonyms:
OPG116 | UNG | UNG_VACCC | vaccinia virus D4/A20
Type:
n/a
Mol. Mass.:
25083.53
Organism:
Vaccinia virus (strain Copenhagen) (VACV)
Description:
P20536
Residue:
218
Sequence:
MNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITKHVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEIINVLLELDNKVPINWAQGFIY
  
Inhibitor
Name:
BDBM208057
Synonyms:
4-(3-((3,5-Dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)butanamide | US9233921, 24c
Type:
Small organic molecule
Emp. Form.:
C19H18Cl2N2OS
Mol. Mass.:
393.33
SMILES:
Cc1ccc2c(Sc3cc(Cl)cc(Cl)c3)c(CCCC(N)=O)[nH]c2c1
Structure:
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