Reaction Details Report a problem with these data
Target
Taste receptor type 2 member 14
Ligand
BDBM211101
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assays
IC50
240.00±n/a nM
Citation
Karanewsky, DS; Fotsing, JR; Tachdjian, C; Arellano, M Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof US Patent US9247759 Publication Date 2/2/2016
More Info.:
Target
Name:
Taste receptor type 2 member 14
Synonyms:
T2R14 | T2R14_HUMAN | TAS2R14 | TRB1 | Taste receptor family B member 1
Type:
n/a
Mol. Mass.:
36183.39
Organism:
Homo sapiens (Human)
Description:
Q9NYV8
Residue:
317
Sequence:
MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
Inhibitor
Name:
BDBM211101
Synonyms:
US9247759, 5-22
Type:
Small organic molecule
Emp. Form.:
C21H24FNO4S
Mol. Mass.:
405.483
SMILES:
OC(=O)C1CCC(CN(Cc2ccc(F)cc2)S(=O)(=O)c2ccccc2)CC1 |(5.71,5.11,;4.22,5.51,;3.83,7,;3.13,4.42,;3.53,2.93,;2.44,1.84,;.96,2.24,;-.38,1.47,;-.38,-.07,;.96,-.84,;.96,-2.38,;-.38,-3.15,;-.38,-4.69,;.96,-5.46,;.96,-7,;2.29,-4.69,;2.29,-3.15,;-1.71,-.84,;-2.48,-2.17,;-.94,-2.17,;-3.04,-.07,;-3.04,1.47,;-4.38,2.24,;-5.71,1.47,;-5.71,-.07,;-4.38,-.84,;.56,3.73,;1.65,4.82,)|