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Target
Taste receptor type 2 member 8
Ligand
BDBM211362
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assays
IC50
20.00±n/a nM
Citation
 Karanewsky, DS; Fotsing, JR; Tachdjian, C; Arellano, M Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof US Patent  US9247759 Publication Date 2/2/2016 
Target
Name:
Taste receptor type 2 member 8
Synonyms:
T2R8 | TA2R8_HUMAN | TAS2R8 | TRB5 | Taste receptor family B member 5 | Taste receptor type 2 member 8 (T2R8)
Type:
n/a
Mol. Mass.:
35897.08
Organism:
Homo sapiens (Human)
Description:
Q9NYW2
Residue:
309
Sequence:
MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
  
Inhibitor
Name:
BDBM211362
Synonyms:
US9247759, 12-13
Type:
Small organic molecule
Emp. Form.:
C23H25N5O5
Mol. Mass.:
451.4751
SMILES:
COc1ccc(CN2C(=O)N(C(=O)C22CC2)c2cnn(Cc3c(C)noc3C)c2)cc1OC
Structure:
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