Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM211897
Substrate
BDBM211682
Meas. Tech.
Neutrophil Elastase Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
<1±n/a nM
Comments
extracted
Citation
More Info.:
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
Inhibitor
Name:
BDBM211897
Synonyms:
US9290459, 47.12 | US9670166, 47.12
Type:
Small organic molecule
Emp. Form.:
C27H23F3N4O6S
Mol. Mass.:
588.555
SMILES:
CS(=O)(=O)c1cc(ccc1[C@H]1N(C(=O)NC2CCOC2)C(=O)N(C2=C1C(=O)CC2)c1cccc(c1)C(F)(F)F)C#N |r,c:25|