Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM164981
Substrate
n/a
Meas. Tech.
FLAP Binding Assay
Ki
2.70±n/a nM
Citation
 Chai, W; Deckhut, C; Dvorak, CA; Eccles, W; Edwards, JP; Goldberg, SD; Krawczuk, PJ; Lebsack, AD; Liu, J; Tanis, VM; Tarantino, KT 1,2,5-Substituted benzimidazoles as flap modulators US Patent  US9682971 Publication Date 6/20/2017 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM164981
Synonyms:
US9067917, 14 | US9682971, 14
Type:
Small organic molecule
Emp. Form.:
C30H25BrFN3O3
Mol. Mass.:
574.44
SMILES:
CC1(C)[C@H]([C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1F)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: