Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM165009
Substrate
n/a
Meas. Tech.
FLAP Binding Assay
Ki
8.40±n/a nM
Citation
 Chai, W; Deckhut, C; Dvorak, CA; Eccles, W; Edwards, JP; Goldberg, SD; Krawczuk, PJ; Lebsack, AD; Liu, J; Tanis, VM; Tarantino, KT 1,2,5-Substituted benzimidazoles as flap modulators US Patent  US9682971 Publication Date 6/20/2017 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM165009
Synonyms:
US9067917, 44 | US9682971, 44
Type:
Small organic molecule
Emp. Form.:
C32H31N3O3
Mol. Mass.:
505.6068
SMILES:
Cc1ccc(Cn2c(nc3cc(OCc4ccc5ccccc5n4)ccc23)C2CCCC[C@H]2C(O)=O)cc1 |r|
Structure:
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