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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM165060
Substrate
n/a
Meas. Tech.
FLAP Binding Assay
Ki
14±n/a nM
Citation
 Chai, W; Deckhut, C; Dvorak, CA; Eccles, W; Edwards, JP; Goldberg, SD; Krawczuk, PJ; Lebsack, AD; Liu, J; Tanis, VM; Tarantino, KT 1,2,5-Substituted benzimidazoles as flap modulators US Patent  US9682971 Publication Date 6/20/2017 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM165060
Synonyms:
US9067917, 95 | US9682971, 95
Type:
Small organic molecule
Emp. Form.:
C37H34N4O4
Mol. Mass.:
598.6903
SMILES:
COc1ccc(cn1)-c1cccc(Cn2c(CC3(CCCC3)C(O)=O)nc3cc(OCc4ccc5ccccc5n4)ccc23)c1
Structure:
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