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Target
Tyrosine-protein kinase SYK
Ligand
BDBM212232
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
93±n/a nM
Comments
extracted
Citation
 Altman, MD; Childers, KK; Di Francesco, ME; Ellis, JM; Fischer, C; Grimm, J; Haidle, AM; Kattar, SD; Northrup, AB; Otte, RD; Petrocchi, A; Schell, AJ; Zhou, H Aminopyrimidines as Syk inhibitors US Patent  US9290490 Publication Date 3/22/2016 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM212232
Synonyms:
US9290490, 2-16
Type:
Small organic molecule
Emp. Form.:
C27H34N4O3S
Mol. Mass.:
494.649
SMILES:
CCC(=O)O[C@@H]1CCC(C[C@H]1C)C(C)(O)c1ncc(s1)-c1cc(C)cc(Nc2nccc(C)n2)c1 |r|
Structure:
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