Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [179-426]
Ligand
BDBM102338
Substrate
n/a
Meas. Tech.
Activity Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
12000±n/a nM
Comments
extracted
Citation
 Shalwitz, R; Gardner, JH Methods for increasing the stabilization of hypoxia inducible factor-α US Patent  US9278930 Publication Date 3/8/2016 
Target
Name:
Egl nine homolog 1 [179-426]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2)
Type:
n/a
Mol. Mass.:
27759.84
Organism:
Homo sapiens (Human)
Description:
EGLN-1-179/426
Residue:
248
Sequence:
LRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM102338
Synonyms:
US10562854, No. C14 | US8536181, C14 | US9278930, C14
Type:
Small organic molecule
Emp. Form.:
C21H22N2O2
Mol. Mass.:
334.4116
SMILES:
CC(NCc1ccn(Cc2ccccc2)c(=O)c1O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: