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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM217311
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Binding Assay
pH
7.5±n/a
IC50
0.86±n/a nM
Comments
extracted
Citation
 Curtin, ML; Sorensen, BK; Heyman, HR; Clark, RF; Woller, KR; Shah, OJ; Michaelides, M; Tse, C; Vasudevan, A; Mack, H; Hansen, TM; Sweis, R; Pliushchev, MA NAMPT and rock inhibitors US Patent  US9302989 Publication Date 4/5/2016 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM217311
Synonyms:
US9302989, 1552
Type:
Small organic molecule
Emp. Form.:
C25H30N4O2
Mol. Mass.:
418.5313
SMILES:
O=C(CC1CC1)N[C@H]1CC[C@H](CC1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 |wU:7.7,10.14,(-5.33,2.9,;-6.1,1.56,;-7.64,1.56,;-8.41,2.9,;-9.75,3.67,;-8.41,4.44,;-5.33,.23,;-3.79,.23,;-3.02,1.56,;-1.48,1.56,;-.71,.23,;-1.48,-1.11,;-3.02,-1.11,;.83,.23,;1.6,-1.11,;3.14,-1.11,;3.91,.23,;5.45,.23,;6.22,1.56,;5.45,2.9,;7.76,1.56,;8.66,2.81,;10.13,2.33,;11.46,3.1,;12.79,2.33,;12.79,.79,;11.46,.02,;10.13,.79,;8.66,.32,;3.14,1.56,;1.6,1.56,)|
Structure:
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