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Target
D(2) dopamine receptor
Ligand
BDBM223069
Substrate
n/a
Meas. Tech.
Dopamine D2 Receptor Activity Assay
Temperature
310.15±n/a K
IC50
220±n/a nM
Comments
extracted
Citation
 Gu, HS; Chen, X; Zhang, JW; Zhang, L; Li, L Synthesis and biological evaluation of novel flavanone derivatives as potential antipsychotic agents. Chem Biol Drug Des 89:353-364 (2017) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM223069
Synonyms:
5-Hydroxy-2-(4-methoxyphenyl)-7-(4-(4-(2-methoxyphenyl)piperazin-1-yl)propoxy)chroman-4-one (7f)
Type:
Small organic molecule
Emp. Form.:
C30H34N2O6
Mol. Mass.:
518.6008
SMILES:
COc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(OCCCN3CCN(CC3)c3ccccc3OC)cc2O1 |r|
Structure:
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