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Target
Acetylcholinesterase
Ligand
BDBM223213
Substrate
n/a
Meas. Tech.
Cholinesterases Inhibition Assay
IC50
2.55e+3± 5e+2 nM
Citation
 Pouramiri, B; Moghimi, S; Mahdavi, M; Nadri, H; Moradi, A; Tavakolinejad-Kermani, E; Firoozpour, L; Asadipour, A; Foroumadi, A Synthesis and anticholinesterase activity of new substituted benzo[d]oxazole-based derivatives. Chem Biol Drug Des 89:783-789 (2017) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache
Type:
Enzyme
Mol. Mass.:
71812.79
Organism:
Electrophorus electricus (Electric eel)
Description:
n/a
Residue:
633
Sequence:
MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFAEPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLYLNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGFLALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDSRPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLIDQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYGAPGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIVGDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHRASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINVDGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAERQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
  
Inhibitor
Name:
BDBM223213
Synonyms:
2-(4-(Thiomorpholinomethyl)phenyl)benzo[d]oxazole (6d)
Type:
Small organic molecule
Emp. Form.:
C18H18N2OS
Mol. Mass.:
310.413
SMILES:
C(N1CCSCC1)c1ccc(cc1)-c1nc2ccccc2o1
Structure:
Search PDB for entries with ligand similarity: