Reaction Details Report a problem with these data
Target
Carboxylic ester hydrolase
Ligand
BDBM223213
Substrate
n/a
Meas. Tech.
Cholinesterases Inhibition Assay
IC50
1.69e+4± 2.6e+3 nM
Citation
 Pouramiri, B; Moghimi, S; Mahdavi, M; Nadri, H; Moradi, A; Tavakolinejad-Kermani, E; Firoozpour, L; Asadipour, A; Foroumadi, A Synthesis and anticholinesterase activity of new substituted benzo[d]oxazole-based derivatives. Chem Biol Drug Des 89:783-789 (2017) [PubMed]  Article 
Target
Name:
Carboxylic ester hydrolase
Synonyms:
BuChE | Butyrlcholinesterase (BuChE) | Butyrylcholine esterase | Butyrylcholinesterase | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | Butyrylcholinesterase (EqBuChE) | Carboxylic ester hydrolase | butyrylcholinesterase precursor
Type:
Protein
Mol. Mass.:
68842.83
Organism:
Equus caballus (Horse)
Description:
Q9N1N9
Residue:
602
Sequence:
MQSWGTIICIRILLRFLLLWVLIGNSHTEEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATKYANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQKNIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEARNRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLTDMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPRVSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTKKFSELGNDAFFYYFEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTKAEEILSRSIMKRWANFAKYGNPNGTQSNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
  
Inhibitor
Name:
BDBM223213
Synonyms:
2-(4-(Thiomorpholinomethyl)phenyl)benzo[d]oxazole (6d)
Type:
Small organic molecule
Emp. Form.:
C18H18N2OS
Mol. Mass.:
310.413
SMILES:
C(N1CCSCC1)c1ccc(cc1)-c1nc2ccccc2o1
Structure:
Search PDB for entries with ligand similarity: