Reaction Details Report a problem with these data
Target
Ezrin
Ligand
BDBM223225
Substrate
n/a
Meas. Tech.
SPR Assay
pH
5.5±n/a
Temperature
298.15±n/a K
Kd
7.492e+4± 7.21e+3 nM
Comments
extracted
Citation
 Rox, K; Rohde, M; Chhatwal, GS; Müller, R Disorazoles Block Group A Streptococcal Invasion into Epithelial Cells Via Interference with the Host Factor Ezrin. Cell Chem Biol 24:159-170 (2017) [PubMed]  Article 
Target
Name:
Ezrin
Synonyms:
Cytovillin | EZR | EZRI_HUMAN | VIL2 | Villin-2 | p81
Type:
Protein
Mol. Mass.:
69408.95
Organism:
Homo sapiens (Human)
Description:
P15311
Residue:
586
Sequence:
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
  
Inhibitor
Name:
BDBM223225
Synonyms:
Disorazole Z
Type:
Small organic molecule
Emp. Form.:
C40H46N2O12
Mol. Mass.:
746.7994
SMILES:
COC(=O)C(C)([C@@H](O)\C=C\C)[C@@H]1C\C=C/C=C/C=C/c2nc(co2)C(=O)O[C@@H](C\C=C/C=C/C=C/c2nc(co2)C(=O)O1)C(C)([C@@H](O)\C=C\C)C(=O)OC |r,c:13,30,t:15,17,32,34|
Structure:
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